Chelsea boss Frank Lampard named winger Hakim Ziyech from the start as Chelsea take on Manchester City in the Premier League st Stamford Bridge.
Werner is also recalled and looks to be playing through the middle as Lampard goes with the German up front ahead of Olivier Giroud and Tammy Abraham.
Pulisic also starts in the front three for the Blues as Lampard’s side look to start 2021 with a victory.
Mendy starts in goal in front of a back four that comprises Cesar Azplicueta, Thiago Silva, Kurt Zouma and Ben Chilwell.
Azpilicueta reaches a big milestone for the Blues today as he racks up his 400th appearance for the club.
The Spaniard joined for just £7 million from Marseille in 2012, and is only the 13th Blues player to reach that figure.
In midfield, N’Golo Kante will shield the back four with Mateo Kovacic and Mason Mount joining him in the midfield.
Hudson-Odoi has been relegated to the bench despite some impressive performances recently for Chelsea.
He is joined on the bench by Kai Havertz, Billy Gilmour, Jorginho and Emerson alongside Abraham and Giroud.
On the City side, they have handed a first start to young goalkeeper Zack Steffen, with Sergio Aguro named on the bench and Ferran Torres absent.
Manchester City were hit by another Covid-related withdrawal on Sunday, meaning they are without six first team players who are now self isolating, including goalkeeper Ederson.
Chelsea: Mendy; Azpilicueta, Zouma, Thiago Silva, Chilwell; Kante, Kovacic, Mount; Pulisic, Ziyech, Werner.